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No cure of the disease is currently possible Our findings suggest that baclofen could be helpful for cataplexy at moderate night-time doses, possibly in older non-adolescent patients and could be a safer and cheaper alternative to GHB. 8 milligram per kilogram twice nightly — the same dosing regimen given to people with narcolepsy — suppressed cataplexy to a greater extent. It is created by eHealthMe based on reports of 85,566 people who have side effects when taking Baclofen from the FDA, and is updated regularly Currently there is no cure for narcolepsy, so treatment focuses on control of symptoms. Disclosure The authors report no conflicts of interest in this work Chronic dosing with R-BAC promoted NREM sleep time, intensity, and consolidation during the light period, longer bouts of wakefulness during the dark period, and sustained suppression of REM sleep and cataplexy. how much cephalexin cost A 2014 mice study found that giving R-baclofen (R-BAC) 2. This rare disease affects 2–5 out of every 10,000 people (1). Cataplexy treatments include antidepressants or a GABA-B agonist, gamma hydroxybutyrate (GHB). There is no curative therapy for narcolepsy. (2) Although the sympathomimetic stimulants, such as amphetamines or methylphenidate, are effective in improving excessive daytime sleepiness in patients with narcolepsy, they have the potential for dependence, have sometimes disabling sympathomimetic side-effects and are associated with tolerance. Most doctors recommend trying modafinil ( Provigil) or armodafinil. GHB is the most effective treatment for cataplexy, but is expensive and can have significant side effects. GHB modestly reduced cataplexy and increased sleep intensity, but did not improve sleep/wake consolidation nor increase NREM sleep time.. Baclofen use in narcolepsy with cataplexy therefore warrants further investigation. A number of medications can help a person stay awake. A recent report of a murine model of narcolepsy-cataplexy suggests R-baclofen has potential efficacy against cataplexy Summary: Narcolepsy is found among people who take Baclofen, especially for people who are female, 50-59 old. Treatment is therefore symptom directed Adverse effects associated with the use of baclofen include depression, hallucinations, dizziness, sensory disturbances, and nausea. It is characterized by excessive sleepiness during the day. Narcolepsy with or without cataplexy Narcolepsy is a neurological disorder that affects the natural cycles of sleeping and waking. The investigators concluded that future studies are warranted,. Background: Narcolepsy is a disabling sleep-wake disorder characterized by the pentad symptoms of excessive daytime sleepiness, sleep paralysis, sleep fragmentation, sleep-related hallucinations, and cataplexy. In narcolepsy without cataplexy, the main symptom is sudden sleepiness. The phase IV clinical study analyzes which people take Baclofen and have Narcolepsy.