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Cephalexin belongs to a group of broad-spectrum antibiotics called cephalosporin. Does cephalexin affect birth control. This can increase the chance of pregnancy Antibiotics are suspected to diminish oral contraceptive efficacy by two main mechanisms: induction of the cytochrome P450 group of hepatic microsomal enzymes and interference with enterohepatic cycling of ethinylestradiol ( 6) ( Table 1 ). Emerging research suggests that high does cephalexin counteract birth control levels of blood glucose are not the whole story for prediabetes. The former mechanism is thought to be most clinically significant and the most well studied No risk, no worry: It's an outdated urban myth that antibiotics interfere with effectiveness of birth control pills. People use antibiotics to fight against bacteria causing infection in their bodies. 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